Hepatitis B virus X gene impacts on the innate immunity and immune-tolerant phase in chronic hepatitis B virus infection.

Kai-Chi Chang Huey-Huey ChuaYa-Hui ChenDaw-Jen TsueiMei-Hui LeeCheng-Lun ChiangYung-Ming JengJia-Feng Wu Huey-Ling Chen Hong-Yuan Hsu Yen-Hsuan Ni Mei-Hwei Chang

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

HBx suppresses IFN-β induction. R87G and I127V mutation restored IFN-β production by preventing MAVS degradation, contributing to curtailing the HBV immune-tolerant phase in CHB patients.

Keyphrases

hepatitis b virus
end stage renal disease
liver failure
newly diagnosed
immune response
ejection fraction
chronic kidney disease
dendritic cells
peritoneal dialysis
prognostic factors
genome wide
dna methylation
genome wide identification
genome wide analysis