Downregulated Mucosal Autophagy, Alpha Kinase-1 and IL-17 Signaling Pathways in Active and Quiescent Ulcerative Colitis.
Luiza Moraes HolstJonas HalfvarsonMarie CarlsonCharlotte Rose HedinRobert KruseCarl Mårten LindqvistDaniel BergemalmSven AlmerFrancesca BressoMaria Ling LundströmDirk RepsilberMauro D'AmatoÅsa KeitaHenrik HjortswangJohan SöderholmJohanna SundinHans TörnblomMagnus SimrénHans StridMaria K MagnussonLena ÖhmanPublished in: Clinical and experimental gastroenterology (2022)
This study indicates that autophagy, alpha kinase-1 and IL-17 signaling pathways are persistently downregulated in UC irrespective of disease activity. Further, UC patients in remission present a unique mucosal environment, potentially preventing patients from reaching and sustaining true homeostasis. These findings may enable better comprehension of the remitting and relapsing pattern of colonic IBD and guide future treatment and prevention of flares.
Keyphrases
- disease activity
- ulcerative colitis
- signaling pathway
- end stage renal disease
- multiple sclerosis
- systemic lupus erythematosus
- ejection fraction
- rheumatoid arthritis
- chronic kidney disease
- newly diagnosed
- cell death
- peritoneal dialysis
- prognostic factors
- oxidative stress
- endoplasmic reticulum stress
- tyrosine kinase
- patient reported outcomes
- protein kinase
- pi k akt
- replacement therapy