Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-19.

Shohei EtoYoko NukuiMiyuki TsumuraYu NakagamaKenichi KashimadaYoko MizoguchiTakanori UtsumiMaki TaniguchiFumiaki SakuraKosuke NomaYusuke YoshidaShinichiro OhshimoShintaro NagashimaKeisuke OkamotoAkifumi EndoKohsuke ImaiHirokazu KaneganeHidenori OhnishiShintaro HirataEiji SugiyamaNobuaki ShimeMasanori ItoHiroki OhgeYasutoshi KidoPaul BastardJean-Laurent CasanovaOsamu OharaJunko TanakaTomohiro MorioSatoshi Okada

Published in: Journal of clinical immunology (2022)

In this study, we revealed that patients with pre-existing naAbs have a much higher risk of life-threatening COVID-19 pneumonia in Japanese population.

Keyphrases

coronavirus disease
sars cov
systemic lupus erythematosus
early onset
respiratory syndrome coronavirus
immune response
zika virus
drug induced
respiratory failure
extracorporeal membrane oxygenation
mechanical ventilation