In vitro mechanical vibration down-regulates pro-inflammatory and pro-fibrotic signaling in human vocal fold fibroblasts.
David HortobagyiTanja GrossmannMagdalena TschernitzMagdalena GrillAndrijana KirschClaus GerstenbergerMarkus GugatschkaPublished in: PloS one (2020)
Our experiments revealed the effect of vibrational stress on hVFF in an inflammatory state. Elevated levels of certain pro-inflammatory/pro-fibrotic factors could be mitigated by additional vibrational excitation in an in vitro setting. These findings corroborate clinical studies which recommend early voice activation following an acute event.
Keyphrases
- energy transfer
- density functional theory
- molecular dynamics simulations
- systemic sclerosis
- endothelial cells
- idiopathic pulmonary fibrosis
- anti inflammatory
- liver failure
- respiratory failure
- induced pluripotent stem cells
- oxidative stress
- single cell
- drug induced
- raman spectroscopy
- aortic dissection
- quantum dots
- molecular dynamics
- stress induced
- hepatitis b virus
- intensive care unit
- extracorporeal membrane oxygenation
- pulmonary fibrosis