Proteinase-activated receptor-2 blockade inhibits changes seen in a chronic murine asthma model.

M AsaduzzamanC DavidsonD NahirneyY FiteihL PuttaguntaHarissios Vliagoftis

Published in: Allergy (2017)

Our data demonstrate that PAR2 signaling plays a key role in CE-induced AHR and airway inflammation/remodeling in long term models of allergic airway inflammation. Targeting PAR2 activation may be a successful therapeutic strategy for allergic asthma.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
lung function
high glucose
diabetic rats
drug induced
electronic health record
cancer therapy
big data
cystic fibrosis
air pollution
endothelial cells
data analysis
quantum dots