Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7.
Haiyan ZhangYan ShaoZihao YaoLiangliang LiuHongbo ZhangJianbin YinHaoyu XieKai LiPinglin LaiHua ZengGuozhi XiaoChun ZengDaozhang CaiXiao-Chun BaiPublished in: Annals of the rheumatic diseases (2022)
mRNA transcription and FBXW7-mediated MKK7 degradation, which consequently stimulated JNK signalling. In particular, inhibition of JNK activity by DTP3, a MKK7 inhibitor, ameliorated chondrocyte senescence and cartilage degeneration CONCLUSIONS: FBXW7 is a key factor in the association between mechanical overloading and chondrocyte senescence and cartilage ageing in the pathology of OA.