COVID-19 mRNA vaccine immunogenicity decay and breakthrough illness in adolescents and young adults with childhood-onset rheumatic diseases.

Joo Guan YeoKai Liang TehWan Ni ChiaYun Xin BookSook Fun HohXiaocong GaoLena DasJinyan ZhangNursyuhadah SutamamSu Li PohAmanda Jin Mei LimShi Huan TayKatherine Nay YaungXin Mei OngJing Yao LeongLin-Fa WangSalvatore AlbaniThaschawee Arkachaisri

Published in: Rheumatology (Oxford, England) (2023)

Over half of AYAs with cRDs had a significant drop in SARS-CoV-2 nAb at 6-month despite an initial robust humoral response. JIA and aTNF usage are predictors of a faster decay rate.

Keyphrases

sars cov
young adults
immune response
respiratory syndrome coronavirus
physical activity
juvenile idiopathic arthritis
coronavirus disease
advanced non small cell lung cancer
childhood cancer
middle aged
early life
epidermal growth factor receptor