Accurate image derived input function in [ 18 F]SynVesT-1 mouse studies using isoflurane and ketamine/xylazine anesthesia.
Alan MirandaDaniele BertoglioSteven StaelensJeroen VerhaeghePublished in: EJNMMI physics (2023)
Image derived left ventricle blood activity calculated with NMF improves absolute activity quantification, and reduces the error in the kinetic modeling fit. These improvements are more pronounced in ketamine-xylazine than in isoflurane anesthetized mice.