Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer.

Laetitia MarisaYuna Blum Gilles Manceau Mira Ayadi Camilla Pilati Karine Le MalicotCôme LepageRamón SalazarDaniela AustAlex Duval Hélène BlonsValérie TalyDavid GentienAudrey RapinatJanick SelvesSophie Mouillet-Richard Valérie Boige Jean François EmileAurélien de ReynièsPierre Laurent-Puig

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

This study shows that CMS-based transcriptomic ITH is frequent in colon cancer and impacts its prognosis. CMS-based transcriptomic ITH may correspond to distinct functional statuses of colon cancer cells, suggesting plasticity between CMS-related cell populations. Transcriptomic ITH deserves further assessment in the context of personalized medicine.

Keyphrases

single cell
rna seq
case report
stem cells
cell therapy