Chemically Selective Imaging of Individual Bonds through Scanning Electron Energy-Loss Spectroscopy: Disulfide Bridges Linking Gold Nanoclusters.

Karolina SokołowskaZhongyue LuanEero Hulkko Christoph Rameshan Noelia Barrabés Vartkess Ara Apkarian Tanja M Lahtinen

Published in: The journal of physical chemistry letters (2020)

As proof-of-principle of chemically selective, spatially resolved imaging of individual bonds, we carry out electron energy-loss spectroscopy in a scanning transmission electron microscopy instrument on atomically precise, thiolate-coated gold nanoclusters linked with 5,5'-bis(mercaptomethyl)-2,2'-bipyridine dithiol ligands. The images allow the identification of bridging disulfide bonds (R-S-S-R) between clusters, and X-ray photoelectron spectra support the finding.

Keyphrases

electron microscopy
high resolution
single molecule
sensitive detection
deep learning
fluorescent probe
mass spectrometry
ionic liquid
computed tomography
convolutional neural network
energy transfer
silver nanoparticles
photodynamic therapy
quantum dots
bioinformatics analysis