Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients.
Jorge I Ramírez SepúlvedaMarika KvarnströmPer ErikssonThomas MandlKatrine Brække NorheimSvein Joar JohnsenDaniel HammenforsMalin V JonssonKathrine SkarsteinJohan G Brunnull nullLars RönnblomHelena Forsblad-d'EliaSara Magnusson BucherEva BaecklundElke TheanderRoald OmdalRoland JonssonGunnel NordmarkMarie Wahren-HerleniusPublished in: Biology of sex differences (2017)
We observe enhanced serological responses and higher frequencies of lymphoma-related extraglandular manifestations in men with pSS. Notably, lymphoma itself was also significantly more common in men. These observations may reflect an aggravated immune activation and a more severe pathophysiological state in male patients with pSS and indicate a personalized managing of the disease due to the influence of the sex of patients with pSS.