Loss of TGFβ-Mediated Repression of Angiopoietin-2 in Pericytes Underlies Germinal Matrix Hemorrhage Pathogenesis.

Jui M DaveRaja ChakrabortyAlex Agyemang Aglaia Ntokou Junichi Saito Praveen Ballabh Kathleen A Martin Daniel M Greif

Published in: Stroke (2024)

This study demonstrates that TGFβ-mediated ANGPT2 repression in pericytes is critical for maintaining blood-brain barrier integrity and identifies pericyte-derived ANGPT2 as an important pathological target for GMH-IVH.

Keyphrases

blood brain barrier
transforming growth factor
cerebral ischemia
genome wide
gene expression