Interleukin-7 and interleukin-15 drive CD4+CD28null T lymphocyte expansion and function in patients with acute coronary syndrome.

Jessica BullenkampVeronica MengoniSatdip KaurIsmita ChhetriParaskevi DimouZoë M J AstroulakisJuan-Carlos Kaski Ingrid E Dumitriu

Published in: Cardiovascular research (2022)

Our novel data show that IL-7 and IL-15 drive the expansion and function of CD28null T cells from ACS patients suggesting that IL-7/IL-15 blockade may prevent expansion of these cells and improve patient outcomes.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
induced apoptosis
acute coronary syndrome
prognostic factors
machine learning
peripheral blood
oxidative stress
patient reported outcomes
signaling pathway
data analysis
nk cells