Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation.

Joongoo LeeRafael TorresDo Soon KimMichelle ByromAndrew D EllingtonMichael C Jewett

Published in: Chemical communications (Cambridge, England) (2020)

We demonstrate in vitro incorporation of cyclic β-amino acids into peptides by the ribosome through genetic code reprogramming. Further, we show that incorporation efficiency can be increased through the addition of elongation factor P.

Keyphrases

amino acid
genome wide
copy number
gene expression
dna methylation