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Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation.

Mahmoud YounsMomen M AskouraHisham A AbbasGouda H AttiaAhdab N KhayyatReham M GodaAhmad J AlmalkiEl-Sayed KhafagyWael A H Hegazy
Published in: OncoTargets and therapy (2021)
The current study aims to be a starting point to generate a hypothesis on the most significant regulatory genes and for a full dissection of the celastrol possible effects on each single gene to prevent the pancreatic cancer growth.
Keyphrases
  • signaling pathway
  • transcription factor
  • genome wide
  • genome wide identification
  • endoplasmic reticulum stress
  • epithelial mesenchymal transition
  • pi k akt
  • dna methylation
  • induced apoptosis
  • genome wide analysis