Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study.
Alexis TabahNiccolò BuettiQuentin StaiqulyStéphane RucklyMurat AkovaAbdullah Tarik AslanMarc LeoneAndrew Conway MorrisMatteo BassettiKostoula ArvanitiJeffrey LipmanRicard FerrerHaibo QiuJosé-Artur PaivaPedro PovoaLiesbet De BusJan J De WaeleFarid ZandShreyas GutteAdel AlsisiKhalid AbidiHendrik BrachtYoshiro HayashiKyeongman JeonMuhammed ElhadiFrançois BarbierJean-François Timsitnull nullPublished in: Intensive care medicine (2023)
HA-BSI was frequently caused by Gram-negative, carbapenem-resistant and DTR pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy. Mortality was high, and at day-28 only a minority of the patients were discharged alive from the hospital. Prevention of antimicrobial resistance and focusing on adequate antimicrobial therapy and source control are important to optimize patient management and outcomes.
Keyphrases
- antimicrobial resistance
- gram negative
- end stage renal disease
- intensive care unit
- newly diagnosed
- ejection fraction
- chronic kidney disease
- multidrug resistant
- healthcare
- staphylococcus aureus
- peritoneal dialysis
- risk factors
- patient reported outcomes
- coronary artery disease
- adipose tissue
- cardiovascular disease
- skeletal muscle
- weight loss
- patient reported
- extracorporeal membrane oxygenation
- cell therapy
- adverse drug
- electronic health record
- smoking cessation