Quantification of O-(2-[18F]fluoroethyl)-L-tyrosine kinetics in glioma.

Thomas KoopmanNiels VerburgRobert C SchuitPetra J W PouwelsPieter WesselingAlbert D WindhorstOtto S HoekstraPhilip C de Witt HamerAdriaan A LammertsmaRonald BoellaardMaqsood Yaqub

Published in: EJNMMI research (2018)

Uptake of [18F]FET was best modelled by a reversible two-tissue compartment model. Reference tissue input models yielded estimates of binding potential which did not correspond well with plasma input-derived DVR-1. In comparison, SUV ratio to contralateral healthy brain tissue showed slightly better performance, if measured at the 60-90 min interval. SUV showed only moderate correlation with VT. VT shows correlation with CBF in tumour.

Keyphrases

white matter
brain injury
binding protein
cerebral ischemia
transcription factor
blood brain barrier
subarachnoid hemorrhage
human health