Targeting Microglia/Macrophages Notch1 Protects Neurons from Pyroptosis in Ischemic Stroke.
Ran ChenHua ZhuZhihui WangYonggang ZhangJin WangYingao HuangLijuan GuChangyong LiXiao-Xing XiongZhihong JianPublished in: Brain sciences (2023)
Our findings elucidate the underlying mechanism of the myeloid Notch1 signaling pathway in regulating neuronal pyroptosis in CIRI, suggesting that targeting myeloid-specific Notch1 is an effective strategy for the treatment of ischemic stroke.