Standardization of CTC AR-V7 PCR assay and evaluation of its role in castration resistant prostate cancer progression.
Stefania TommasiBrunella PilatoClaudia CarellaAntonia LasorellaKatia DanzaIvan ValliniSimona De SummaEmanuele NaglieriPublished in: The Prostate (2018)
The standardized procedure has high sensitivity and specificity and enables the detection and quantification of the spliced variant with respect to the full length AR (AR-FL) mRNA in CTC DNA purified from the blood of patients with CRPC. This procedure has been further validated in a consecutive series of patients with mCRPC, confirming its role as prognostic biomarker.