Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis.
Elizabeth C OkaforKatherine Huppler HullsiekDarlisha A WilliamsJames E ScrivenJoshua RheinHenry W NabetaAbdu Kisekka MusubireRadha RajasinghamConrad MuzooraCharlotte SchutzGraeme MeintjesDavid B MeyaDavid R BoulwarePublished in: Mediators of inflammation (2020)
Based on our analysis of 21 biomarkers, serum and cerebrospinal fluid immune responses do not correlate. There appears to be a distinct immune environment in terms of soluble biomarkers in the vasculature versus end-organ site of infection. While this is a model of HIV-related cryptococcal meningitis, we postulate that assuming the blood compartment is representative of the immune function at the end-organ site of infection may not be appropriate.