Changes in heart morphometric parameters over the course of a monocrotaline-induced pulmonary arterial hypertension rat model.
Mateusz Krystian HołdaElżbieta SzczepanekJoanna BielawskaNatalia PalkaDorota WojtysiakPaulina FrączekMichał NowakowskiNatalia SowińskaZbigniew ArentPiotr PodolecGrzegorz KopećPublished in: Journal of translational medicine (2020)
PAH leads to multidimensional changes in morphometric cardiac parameters. Right ventricle morphological and functional failure develop gradually from early stage of PAH, while left ventricle changes develop at the end stages of PAH.
Keyphrases
- pulmonary arterial hypertension
- pulmonary artery
- pulmonary hypertension
- early stage
- polycyclic aromatic hydrocarbons
- high glucose
- heart failure
- mitral valve
- diabetic rats
- left ventricular
- drug induced
- squamous cell carcinoma
- coronary artery
- atrial fibrillation
- endothelial cells
- oxidative stress
- congenital heart disease
- lymph node