Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically.

Xin ZhangBo HuYun-Fan SunXiao-Wu HuangJian-Wen ChengAo HuangHai-Ying ZengShuang-Jian QiuYa CaoJia FanJian ZhouXin-Rong Yang

Published in: Clinical and translational medicine (2021)

ATO induced the differentiation of HCC CSCs and potentiated the cytotoxic effects of 5-FU/cisplatin through synergistic inhibition of the LIF/JAK1/STAT3 and NF-kB signaling pathways. These results offer new insights for the clinical treatment of HCC.

Keyphrases

signaling pathway
cancer stem cells
pi k akt
induced apoptosis
epithelial mesenchymal transition
lps induced
high glucose
diabetic rats
oxidative stress
drinking water
nuclear factor
drug induced
cell proliferation
inflammatory response
toll like receptor
smoking cessation