EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity.

Fenglin Cai Xiuding Yang Gang Ma Pengliang WangMengmeng ZhangNannan Zhang Rupeng Zhang Han LiangYongzhan NieCheng Dong Jingyu Deng

Published in: British journal of cancer (2024)

EGLN3 has the potential to hinder the spread of GC cells through a nonenzymatic mechanism, thereby shedding light on the complex nature of GC progression.

Keyphrases

signaling pathway
induced apoptosis
cell cycle arrest
pi k akt
gas chromatography
oxidative stress
lps induced
endoplasmic reticulum stress
nuclear factor
cell death
inflammatory response
mass spectrometry
immune response