ER stress arm XBP1s plays a pivotal role in proteasome inhibition-induced bone formation.
Dan ZhangKim De VeirmanRong FanQiang JianYuchen ZhangLi LeiHolly EvansYanmeng WangLei LeiBaiyan WangRamone A WilliamsonAndrew ChantryPengcheng HeAng LiHendrik De RaeveKarin VanderkerkenAili HeJinsong HuPublished in: Stem cell research & therapy (2020)
These results demonstrated that XBP1s is a master regulator of PI-induced osteoblast differentiation. Activation of IRE1α-XBP1s ER stress signaling can promote osteogenesis, thus providing a novel strategy for the treatment of myeloma bone disease.