High-dose Tiger-Gian formula protects the knee joint from surgically induced osteoarthritis in rats.
Pu-Wei HouShan-Chi LiuGregory J TsayYuan-Shiun ChangHui-Chi HuangChih-Hsin TangHen-Hong ChangPublished in: International journal of rheumatic diseases (2022)
High-dose TGF induced the smallest amount of KOA-associated bone loss. Anti-inflammatory, anti-oxidative, and immunomodulatory effects of TGF were accompanied by reductions in proinflammatory cytokines and improvements in pain and function. TGF-induced anti-osteoporotic activity and inhibition of cartilage degradation were reflected by micro-CT and histological analysis. The findings help to explain how TGF alleviates symptoms of KOA.
Keyphrases
- high dose
- transforming growth factor
- high glucose
- diabetic rats
- bone loss
- low dose
- anti inflammatory
- rheumatoid arthritis
- oxidative stress
- stem cell transplantation
- chronic pain
- magnetic resonance imaging
- endothelial cells
- epithelial mesenchymal transition
- bone mineral density
- pain management
- magnetic resonance
- spinal cord
- physical activity
- spinal cord injury
- signaling pathway
- extracellular matrix
- postmenopausal women
- dual energy