Role of TPMT and ITPA variants in mercaptopurine disposition.

Tina Gerbek Maria Ebbesen Jacob Nersting Thomas Leth Frandsen Malin Lindqvist Appell Kjeld Schmiegelow

Published in: Cancer chemotherapy and pharmacology (2018)

TPMT and ITPA genotypes significantly influence the metabolism of 6MP. DNA-TG may prove to be a more relevant pharmacokinetic parameter for monitoring 6MP treatment intensity than cytosolic metabolites. Prospective trials are needed to evaluate the usefulness of DNA-TGN for individual dose adjustments in childhood ALL maintenance therapy.

Keyphrases

circulating tumor
cell free
single molecule
ms ms
copy number
high intensity
circulating tumor cells
dna methylation