Microarray data analysis of antileukemic action of Cinnamoylated benzaldehyde LQB-461 in Jurkat cell line.

Rachell R C Thimoteo Pedro Nicolau Neto Debora S S Costa Fabrício da Mota Ramalho Costa Douglas Cazaroti Brito Paulo R R Costa Tatiana de Almeida Simão Ayres G Dias Graça Justo

Published in: Molecular biology reports (2024)

These results suggest that this synthetic molecule LQB-461 induces cell death by apoptosis in Jurkat cells through intrinsic and extrinsic pathways and inhibits autophagy, overcoming some mechanisms of cell resistance related to this process, which differentiates LQB-461 of other drugs used for the leukemia treatment.

Keyphrases

cell death
cell cycle arrest
data analysis
induced apoptosis
endoplasmic reticulum stress
oxidative stress
pi k akt
acute myeloid leukemia
cell therapy
signaling pathway
stem cells
combination therapy
smoking cessation