Characterization of SARS-CoV-2 worldwide transmission based on evolutionary dynamics and specific viral mutations in the spike protein.

Jiluo LiuXi ChenYan LiuJiansheng LinJiaying ShenHongwei ZhangJianhua YinRui PuYibo DingGuang-Wen Cao

Published in: Infectious diseases of poverty (2021)

SARS-CoV-2 strains might have originated in several countries simultaneously under certain evolutionary pressure. Travel restrictions might cause location-specific SARS-CoV-2 clustering. The SARS-CoV-2 evolution appears to facilitate its transmission via altering the affinity to ACE2 or immune evasion.

Keyphrases

sars cov
respiratory syndrome coronavirus
genome wide
small molecule
gene expression
single cell
mass spectrometry
rna seq
angiotensin converting enzyme
binding protein
protein protein
amino acid