A multi-trait GWAS identifies novel genes influencing albuminuria.
Hsiao-Mei TsaoTai-Shuan LaiYi-Cheng ChangChia-Ni HsiungI-Jung TsaiYu-Hsiang ChouVin-Cent WuShuei-Liong LinYung-Ming ChenPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024)
The findings of this multi-trait GWAS suggest that primary cilia play a role in sensing mechanical stimuli, leading to albumin endocytosis. The priority list of genes warrants further translational investigation to reduce albuminuria.