High-fat diet consumption alters energy metabolism in the mouse hypothalamus.

Blanca LizarbeAntoine CherixJoão M N DuarteJean-René CardinauxRolf Gruetter

Published in: International journal of obesity (2005) (2018)

We report changes that reveal a high-fat diet-induced alteration of hypothalamic metabolism and neurotransmission that is quantifiable by 1H and 13C MRS in vivo, and present the first evidence of the extension of the inflammation pathology to a localized metabolic imbalance.

Keyphrases

high fat diet
high fat diet induced
insulin resistance
adipose tissue
oxidative stress
metabolic syndrome
skeletal muscle
genome wide
type diabetes
single cell
gene expression
dna methylation