Quantification and molecular correlates of tertiary lymphoid structures in primary prostate cancer.
Mohammed ShahaitAlexander K HakanssonReba E DanielKareem HosnyElai DavicioniSeagle Yang LiuAlex SandbergDavid I LeePriti LalPublished in: The Prostate (2024)
Clusters of inflammatory cells in the RP specimen can be divided spatially into PT TLS and IT-TLS, each with its unique molecular correlates of tumor immune microenvironment. The presence of TLS is positively correlated with MHC signatures, T- cell and B-cell cluster signatures but, negatively correlated with immune suppressive signatures. A subset of prostate cancer demonstrate a robust inflammatory response, and warrant further characterization in larger cohorts.
Keyphrases
- prostate cancer
- inflammatory response
- radical prostatectomy
- genome wide
- induced apoptosis
- cell cycle arrest
- stem cells
- oxidative stress
- high resolution
- lipopolysaccharide induced
- cell death
- lps induced
- endoplasmic reticulum stress
- cell proliferation
- gene expression
- toll like receptor
- signaling pathway
- mass spectrometry