DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma.
Meng-Jia SongChaoqi ZhangShaoyan ChengDijun OuyangYu PingJieying YangYao-Jun ZhangYan TangHao ChenQi-Jing WangYong-Qiang LiJia HeTong XiangYi-Zhuo ZhangJian-Chuan XiaPublished in: Cancer research (2024)
TMCO6 is a receptor for DNA of NETs that mediates CD8+ T-cell dysfunction in HCC, indicating that the NET-TMCO6 axis is a promising target for overcoming immunosuppression in liver cancer.