Limited sampling strategies for accurate determination of extended half-life factor VIII pharmacokinetics in severe haemophilia A patients.
Alanna McEneny-KingPierre ChelleMargaret H GoggansPatricia J BarkerTimothy W JacobsEllis J NeufeldUlrike M ReissJohn C PanettaPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2021)
The PK of rFVIIIFc can be accurately estimated using only peak and trough samples, provided that knowledge of prior doses is incorporated and the PK study is planned on an appropriate day within the dosing regimen.