Identification of polypharmacy patterns in new-users of metformin using the Apriori algorithm: a novel framework for investigating concomitant drug utilization through association rule mining.

Maria Luisa FaquettiAdrian Martinez-De la TorreTheresa BurkardGuillaume ObozinskiAndrea M Burden

Published in: Pharmacoepidemiology and drug safety (2022)

This study is the first to identify and quantify commonly prescribed combinations of drugs compounds in patients with polypharmacy using the Apriori algorithm. The high polypharmacy prevalence at all strata indicates the need to optimize polypharmacy to minimize DDI and ADR. This article is protected by copyright. All rights reserved.

Keyphrases

adverse drug
machine learning
deep learning
risk factors
emergency department
electronic health record
drug induced
neural network
bioinformatics analysis