Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators.

Jiakai HouYunfei WangLeilei ShiYuan ChenChunyu XuArash SaeediKe PanRitu BohatNicholas A EganJodi A McKenzieRina M MbofungLeila J WilliamsZhenhuang YangMing SunXiaofang LiangJordi Rodon AhnertNavin VaradarajanCassian YeeYiwen ChenPatrick Hwu Weiyi Peng

Published in: Journal for immunotherapy of cancer (2022)

Collectively, the data provide a rich resource of novel targets for rational immuno-oncology combinations.

Keyphrases

genome wide
electronic health record
dna methylation
big data
transcription factor
crispr cas
high throughput
gene expression
data analysis
single cell