Hepatitis C virus direct-acting antivirals therapy impacts on extracellular vesicles microRNAs content and on their immunomodulating properties.

Laura SantangeloVeronica BordoniClaudia MontaldoEleonora CiminiAlessandra ZingoniCecilia BattistelliGianpiero D'OffiziMaria R CapobianchiAngela SantoniMarco TripodiChiara Agrati

Published in: Liver international : official journal of the International Association for the Study of the Liver (2018)

Enrichment of immunomodulatory microRNAs in exosomes of HCV patients was correlated with their inhibitory activity on innate immune cells function. Direct-acting antivirals (DAA) treatment was observed to revert both microRNA content and functional profiles of systemic exosomes towards those of healthy donors. Exosome-associated microRNAs may provide valuable biomarkers to monitor immune response recovery.

Keyphrases

hepatitis c virus
immune response
end stage renal disease
mesenchymal stem cells
human immunodeficiency virus
stem cells
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
dendritic cells
inflammatory response
drug induced