Gonadotropic status in adult women with pituitary stalk interruption syndrome.

Among 56 women with PSIS, 36 did not experience spontaneous puberty. Of these, 13 underwent ovarian stimulation resulting in 7 women having a total of 11 children. In the subgroup with spontaneous puberty (n = 20), 4 had a total of 8 pregnancies while 6 developed secondary gonadotropic deficiency. Women with PSIS had fewer children than controls (0.33 versus 0.63, p = 0.04). Median height was also lower (160.5 cm versus 165.0 cm, p < 0.0001). Although mean blood pressure was lower in women with PSIS compared to controls, (111.3/65.9 ± 11.2/8.1 mmHg vs 118.7/72.1 ± 10.1/7.7 mmHg, p < 0.001), there were no significant differences in other metabolic parameters, notably BMI and lipid profile. Employment/academic status was not different in the two groups but fewer women with PSIS were in relationships (42% versus 57.6% in controls, p = 0.02). The fertility prognosis in patients with PSIS needs optimization. Patients should be informed about the likelihood of declining gonadotropic function over time.