Selective DRD2 Antagonist and ClpP Agonist ONC201 in a Recurrent Non-midline H3 K27M-mutant Glioma Cohort.

Yazmin OdiaMatthew D HallTimothy Francis CloughesyPatrick Y WenIsabel C Arrillaga-RomanyDoured DaghistaniMinesh P MehtaRohinton S TaraporeSamuel C RamageJoshua E Allen

Published in: Neuro-oncology (2024)

H3K27M-mutant diffuse gliomas occasionally occur in nonmidline cerebrum. ONC201 exhibits activity in H3K27M-mutant gliomas irrespective of CNS location.

Keyphrases

high grade
wild type
low grade
blood brain barrier