The Impact of Pinus koraiensis Leaf Extract Consumption on Postprandial ApoB100 and Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Participants Subjected to an Oral High-Fat Challenge.
Soo-Yeon ParkTae Gwon ParkKwanyong ChoiKyeong Jin KimJi Yeon KimPublished in: Nutrients (2024)
Pinus koraiensis (PK) leaf extract, derived from Korean pine byproducts, holds promise for alleviating postprandial hyperlipidemia. In this study, we investigated the potential of PK leaf extract for modulating postprandial hyperlipidemia in adults with normal or borderline fasting triglyceride levels. In a randomized, double-blind, parallel design, 70 subjects were randomly assigned to either the placebo or PK group for 4 weeks. After 4 weeks of consuming PK leaf extract, the results indicated a trend toward decreased serum apolipoprotein B-100 (ApoB100) levels 2 h after a high-fat challenge. Furthermore, significant improvements were observed in the incremental area under the curve (iAUC) at 0-4 h and 2-4 h compared to baseline, particularly among individuals with a higher body weight (>61.35 kg) and daily caloric intake (>1276.5 kcal). Based on these findings, PK leaf extract may have beneficial effects on postprandial lipoprotein metabolism, especially among individuals with a relatively high body weight and caloric intake.
Keyphrases
- body weight
- double blind
- blood glucose
- placebo controlled
- clinical trial
- high fat diet
- phase iii
- study protocol
- phase ii
- gestational age
- physical activity
- insulin resistance
- type diabetes
- drinking water
- glycemic control
- weight gain
- high fat diet induced
- blood pressure
- body mass index
- high resolution
- machine learning
- big data
- metabolic syndrome
- deep learning
- climate change
- artificial intelligence
- weight loss