Inhibition of Phosphoglycerate Mutase 5 Reduces Necroptosis in Rat Hearts Following Ischemia/Reperfusion Through Suppression of Dynamin-Related Protein 1.

Lang SheHua TuYin-Zhuang ZhangLi-Jing TangNian-Sheng LiQi-Lin MaBin LiuQingjie LiXiu-Ju LuoJun Peng

Published in: Cardiovascular drugs and therapy (2019)

Inhibition of PGAM5 can reduce necroptosis in I/R-treated rat hearts through suppression of Drp1; there is a positive feedback between RIPK1 and PGAM5, and PGAM5 might serve as a novel therapeutic target for prevention of myocardial I/R injury.

Keyphrases

oxidative stress
left ventricular
heart failure
newly diagnosed