Preclinical mouse model of optical coherence tomography for subcortical brain imaging without dissection.
Jae Meen LeeInho HanKyoung Hyup NamDong Hwan KimSeunghwan SongHeejeong ParkHongki KimMinkyu KimJeonghun ChoiJae Il LeePublished in: Journal of biophotonics (2021)
The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to identify internal brain lesions, specifically intracerebral hemorrhage, without dissection. Mice with artificially injected brain hematomas were used to test the OCT system, and the recorded images were compared with microscopic images of the same mouse brains after hematoxylin and eosin staining. The intracranial structures surrounding the hematomas were clearly visualized by the OCT system without dissection. These images reflect the ability of OCT to determine the extent of a lesion in several planes. OCT is a useful technology, and these findings could be used as a starting point for future research in intraoperative imaging.
Keyphrases
- optical coherence tomography
- diabetic retinopathy
- optic nerve
- white matter
- high resolution
- resting state
- mouse model
- functional connectivity
- cerebral ischemia
- brain injury
- deep learning
- stem cells
- type diabetes
- multiple sclerosis
- metabolic syndrome
- machine learning
- patients undergoing
- mass spectrometry
- cell therapy
- mesenchymal stem cells
- bone marrow
- fluorescence imaging
- high fat diet induced