Islands of genomic stability in the face of genetically unstable metastatic cancer.

Kirsten Bowland Jiaying LaiAlyza SkaistYan ZhangSelina Shiqing K TehNicholas J RobertsElizabeth ThompsonSarah J WheelanRalph H HrubanRachel KarchinChristine A Iacobuzio-DonahueJames R Eshleman

Published in: bioRxiv : the preprint server for biology (2024)

Regions of truncal LOH are strongly retained in the presence of genetic instability, and therefore represent genetic vulnerabilities in pancreatic adenocarcinomas. A CRISPR-based gene therapy approach targeting these regions may be a novel way to genetically target metastatic cancer.

Keyphrases

gene therapy
papillary thyroid
squamous cell
genome wide
squamous cell carcinoma
small cell lung cancer
copy number
crispr cas
dna methylation
gene expression
drug delivery