Inhibition of BET Proteins during Adolescence Affects Prefrontal Cortical Development: Relevance to Schizophrenia.

Wiktor BileckiAgnieszka Wawrzczak-BargiełaIwona Majcher-MaślankaMagdalena ChmelovaMarzena Maćkowiak

Published in: International journal of molecular sciences (2021)

MAM-induced schizophrenia-like abnormalities were observed only in males, while adolescent JQ1 treatment affected memory recognition and altered the molecular and proteomic landscape in the mPFC of both sexes. Thus, transient adolescent inhibition of the BET family might prompt permanent alterations in the mPFC.

Keyphrases

bipolar disorder
young adults
working memory
mental health
high glucose
depressive symptoms
diabetic rats
oxidative stress
drug induced
single molecule
endothelial cells
replacement therapy