Selective perforant-pathway atrophy in Huntington disease: MRI analysis of hippocampal subfields.
Pierre WibawaMark WalterfangCharles B MalpasYifat Glikmann-JohnstonGovinda PoudelAdeel RaziAnthony J HannanDennis VelakoulisNellie Georgiou-KaristianisPublished in: European journal of neurology (2023)
Hippocampal subfields atrophy in early symptomatic HD affects key regions of the perforant-pathway, which may implicate the distinctive memory impairment at this stage of illness. Their volumetric associations with genetic and clinical markers suggest the selective susceptibility of these subfields to mutant Huntingtin and disease progression.