Sensory-Behavioral Deficits in Parkinson's Disease: Insights from a 6-OHDA Mouse Model.

Savannah R LinenNelson H ChangEllen J Hess Garrett B Stanley Christian Waiblinger

Published in: bioRxiv : the preprint server for biology (2024)

This study explores sensory-motor aspects of Parkinson's disease using a 6-OHDA mouse model. Leveraging the mouse whisker system, we reveal diverse deficits in tactile sensation behavior due to dopamine depletion. Our findings emphasize the importance of sensory assessments in understanding the diverse spectrum of PD symptoms.

Keyphrases

mouse model
traumatic brain injury
uric acid
gene expression
single cell
physical activity
depressive symptoms
sleep quality
prefrontal cortex