Lipocalin-2 aggravates blood-brain barrier dysfunction after intravenous thrombolysis by promoting endothelial cell ferroptosis via regulating the HMGB1/Nrf2/HO-1 pathway.

Jie LiuShu-Yan PangSheng-Yu ZhouQian-Yan HeRuo-Yu ZhaoYang QuYi YangZhen-Ni Guo

Published in: Redox biology (2024)

LCN2 aggravated BBB disruption after thrombolysis by promoting endothelial cell ferroptosis via regulating the HMGB1/Nrf2/HO-1 pathway, this may provide a promising therapeutic target for the prevention of HT after IVT.

Keyphrases

blood brain barrier
endothelial cells
oxidative stress
pulmonary embolism
cell death
acute ischemic stroke
cerebral ischemia
pi k akt
high glucose
high dose
low dose
signaling pathway
brain injury