Temporomandibular Disorders Slow Down the Regeneration Process of Masticatory Muscles: Transcriptomic Analysis.
Cinzia SindonaMichele Runci AnastasiLuigi ChiricostaAgnese GugliandoloSerena SilvestroPlacido BramantiPiero CasconeEmanuela MazzonPublished in: Medicina (Kaunas, Lithuania) (2021)
Background and Objectives: Musculoskeletal injuries represent a pathological condition due to limited joint motility and morphological and functional alterations of the muscles. Temporomandibular disorders (TMDs) are pathological conditions due to alterations in the musculoskeletal system. TMDs mainly cause temporomandibular joint and masticatory muscle dysfunctions following trauma, along with various pathologies and inflammatory processes. TMD affects approximately 15% of the population and causes malocclusion problems and common symptoms such as myofascial pain and migraine. The aim of this work was to provide a transcriptomic profile of masticatory muscles obtained from TMD migraine patients compared to control. Materials and Methods: We used Next Generation Sequencing (NGS) technology to evaluate transcriptomes in masseter and temporalis muscle samples. Results: The transcriptomic analysis showed a prevalent downregulation of the genes involved in the myogenesis process. Conclusions: In conclusion, our findings suggest that the muscle regeneration process in TMD migraine patients may be slowed, therefore therapeutic interventions are needed to restore temporomandibular joint function and promote healing processes.
Keyphrases
- end stage renal disease
- stem cells
- ejection fraction
- chronic kidney disease
- newly diagnosed
- skeletal muscle
- chronic pain
- prognostic factors
- single cell
- mental health
- gene expression
- oxidative stress
- physical activity
- escherichia coli
- neuropathic pain
- pain management
- dna methylation
- depressive symptoms
- patient reported outcomes
- genome wide
- cystic fibrosis
- candida albicans
- trauma patients