Piperine improves levodopa availability in the 6-OHDA-lesioned rat model of Parkinson's disease by suppressing gut bacterial tyrosine decarboxylase.

Xiaolu HuLan YuYatong LiXiaoxi LiYimeng ZhaoLijuan XiongJiaxuan AiQijun ChenXing WangXiaoqing ChenYinying BaYaonan WangXia Wu

Published in: CNS neuroscience & therapeutics (2023)

Oral administration of L-dopa combined with PIP can improve L-dopa availability and brain DA level in 6-OHDA-lesioned rats by suppressing intestinal bacterial TDC.

Keyphrases

parkinson disease
white matter
resting state
deep brain stimulation