Factors in the Neonatal Period Associated With Pulmonary Hypertension at 28 Days of Life in Broncho-Pulmonary Dysplasia.
Nguyen Thi Hai AnhTran Minh DienLe Thi HaPham Thao NguyenDang Thi Hai VanPublished in: Global pediatric health (2024)
Objectives. To identify factors associated with pulmonary hypertension (PH) at 28 days of life in preterm infants with bronchopulmonary dysplasia (BPD). Methods . This observational study included 128 premature infants with BPD between January 2022 and February 2023 from the neonatal intensive care unit of Vietnam National Children's Hospital. Results . PH was observed using echocardiography in 29 patients (22.66%). The prevalence of severe BPD in the PH group (62.07%) was significantly higher than that in the non-PH group (18.18%). The multivariate logistic regression showed 2 predictors of PH in BPD: invasive mechanical ventilation up to 28 days of life (odds ratio [OR]:9.440; 95% confidence interval [CI]: 3.090-28.833; P < .001) and history of shock (OR: 2.962; 95% CI: 1.067-8.225; P = .037). Conclusion. We found 2 predictors of PH at 28 days of life in BPD: invasive mechanical ventilation up to 28 days of life and history of shock.
Keyphrases
- mechanical ventilation
- pulmonary hypertension
- preterm infants
- acute respiratory distress syndrome
- intensive care unit
- pulmonary artery
- pulmonary arterial hypertension
- computed tomography
- young adults
- risk factors
- newly diagnosed
- left ventricular
- coronary artery
- heart failure
- early onset
- low birth weight
- extracorporeal membrane oxygenation
- electronic health record
- patient reported outcomes
- data analysis