Incidence and factors associated with treatment failure among HIV infected adolescent and adult patients on second-line antiretroviral therapy in public hospitals of Northern Ethiopia: Multicenter retrospective study.
Adisu Zenebe HaftuAbraham Aregay DestaNega Mamo BezabihAlemayehu Bayray KahsayKibriti Mehari KidaneYodit ZewdieTewolde Wubayehu WoldearegayPublished in: PloS one (2020)
Incidence of second-line ART treatment failure in the first 2 years of follow-up was high. The rate of second-line ART failure was higher in patients who started second-line ART with poor drug adherence, CD4 count <100 cells/mm3, TB co-morbidity, age >45 years, and being in WHO stage IV. Therefore, intensive counseling and adherence support should be given along with strong TB screening. Moreover, the government of Ethiopia should consider endorsing third-line ART drugs after careful cost-benefit analysis.
Keyphrases
- hiv infected
- antiretroviral therapy
- human immunodeficiency virus
- hiv infected patients
- hiv aids
- hiv positive
- healthcare
- mental health
- young adults
- induced apoptosis
- mycobacterium tuberculosis
- type diabetes
- clinical trial
- metabolic syndrome
- emergency department
- men who have sex with men
- cell proliferation
- hiv testing
- adverse drug
- oxidative stress
- weight loss
- insulin resistance